Soskic Group
Il Soskic Group si concentra sui meccanismi molecolari, cellulari e genetici alla base delle funzioni effettrici del sistema immunitario, con particolare attenzione alla biologia delle cellule B e alla diversificazione anticorpale. Il nostro obiettivo è comprendere come le reti di regolazione genica controllino la differenziazione e l’attivazione delle cellule B, come avvengono le decisioni relative al cambio di classe anticorpale e come la variabilità genetica modelli questi processi, influenzando le risposte immunitarie e la predisposizione alle malattie autoimmuni.
Il nostro Gruppo adotta un approccio fortemente interdisciplinare, integrando metodi sperimentali e computazionali in immunologia, genomica e biologia cellulare. Combiniamo saggi immunologici avanzati con tecnologie genomiche ad alto rendimento e analisi computazionali per analizzare la regolazione molecolare dell’attivazione delle cellule B e della diversificazione anticorpale. Parallelamente, studiamo come la variabilità genetica e la disregolazione dell’attivazione delle cellule B contribuiscano al rischio di malattie autoimmuni.
Per informazioni, si prega di contattare [email protected]
Membri del gruppo
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Blagoje Soskic
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Negin Alizadehmohajer
PhD Student -
Chiara Caime
Scientific Visitor -
Pietro Demela
PhD Student -
Laura Esposito
Specialist -
Pietro Marchesan
PhD Student -
Manendra Singh Negi
Postdoc -
Leonardo Nossa
Postgraduate Intern -
Juan Marcos Oviedo
Postdoc -
Irene Sechi
Postdoc
Pubblicazioni
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04/2026 - Mol Syst Biol
Competing gene regulatory networks drive naive and memory B cell differentiation
Elucidating the gene regulatory networks (GRNs) that control human B cell differentiation is crucial for understanding immune responses to infection, vaccination, and autoimmunity. Here, we map the GRNs guiding naive and memory B cell differentiation. Early in activation, both cell types engage highly similar GRNs. However, at later stages, naive B cells diverge into two […]
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03/2026 - Clinical and Experimental Immunology
An imbalance between CD80 and CD86 levels and CD4 regulatory T cell number and transendocytosis function exists in the liver in autoimmune hepatitis
Impairment in Regulatory CD4 T cells (Treg) number and function have been implicated in autoimmune hepatitis (AIH). Treg are critical regulators of CD28 costimulation through CTLA4-mediated CD80 and CD86 control. We sought evidence for hepatic Treg frequency, phenotype, and function, and CD80/CD86 availability in AIH. Hepatic immune cells were isolated from eight patients with AIH […]
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01/2026 - Int. J. Mol. Sci.
IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a wide range of clinical manifestations modulated by genetic factors. The aim of this study was to identify genetic determinants of severe COVID-19 affecting protein sequence to gain insight into disease pathogenesis. Variants prioritized in two patients requiring lung transplant were tested in the Milan FOGS […]
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08/2025 - FEBS Letters
Regulation of mRNA metabolism in immune cells
Rapid activation of immune cells is critical for host defence. While transcriptional regulation is essential for initiating the immune response, emerging evidence highlights the role of post-transcriptional mechanisms in controlling the speed and intensity of the immune reaction. Splicing, polyadenylation, translation and decay are all regulated to fine-tune the expression of genes crucial for immune […]
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05/2023 - Nature Communications
Cross-disorder genetic analysis of immune diseases reveals distinct gene associations that converge on common pathways
Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci associated with immune-mediated diseases. To assess the extent of the genetic sharing across nine immune-mediated diseases we apply genomic structural equation modelling to GWAS data from European populations. We identify three disease groups: gastrointestinal tract diseases, rheumatic and systemic diseases, and allergic diseases. Although loci […]
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