Human Technopole

A study by the Pigino Group at Human Technopole reveals that the conversion from anterograde to retrograde intraflagellar transport requires the complete disassembly of anterograde trains at the ciliary tip and provides the mechanisms for direction-specific cargo binding and transport in cilia.

The Glastonbury Group is among the recipients of the Data Insights Cycle 3 awards. The aim of the grant is to develop a machine learning model that identifies disease-relevant cell subpopulations whilst predicting a phenotype/disease of interest from large-scale single-cell RNA-seq data.

Meet Paolo Swuec, responsible for running the Italy’s first Cryo-EM Facility and, today, Head of the National Facility for Structural Biology at Human Technopole: a hub for cutting-edge research, facilitating the structural characterization of biological entities, ranging from tissues to amino acid side-chains.

In collaboration with an international team of scientists, HT researchers identified a missense mutation in a gene involved in brain-intrinsic immunity as the genetic cause of SARS-CoV-2 brainstem encephalitis.

Human Technopole is opening its National Facilities, providing advanced equipment and technologies accessible through calls for proposals open to the Italian scientific community. Projects will be selected by a commission of international experts. Scientists will have access to five new dedicated facilities, which act as catalysts for open innovation in the life sciences sector, crucial for research and the health of Italians.

Five years since its inception, Human Technopole is now a dynamic institute where researchers from around the world have laid the foundations for unravelling the fundamental mechanisms of life across multiple biological scales – molecules, cells, tissues, organs, organisms, populations – in space and time.