According to the project, the Human Technopole campus will host seven research centres and four scientific facilities, that will provide services and technologies to support the research centers. Each centre will include its own laboratories and will collaborate with universities, research centres and hospitals.
Human Technopole, will be a large-scale national research infrastructure. Over 35.000sqm will be dedicated to interdisciplinary laboratories starting from data science, genomics, neuro-genomics, computational and structural biology.
The first areas of research currently being developed are:
It will pursue research aimed at uncovering the complex mechanisms governing gene expression and how heritable genetic information translates into phenotypic traits. Applied to humans, and in the context of so-called ‘precision medicine’ this type of research can be instrumental in identifying molecular targets and markers for disease prevention, early detection and personalised treatments.
It will support and integrate with research pursued by the Centre for Genomics. It will take computational and bioinformatics approaches to study disease-associated biological processes, mainly by developing advanced technologies, novel algorithms and software for computational simulations and big data analysis.
It will combine basic and translational research using different systems (from animal models over stem-cell derived neuron cultures to organoids) investigating nervous system structure-function and neuronal development, with attention to molecular mechanisms underlying neural disorders including neurodegenerative diseases.
It will aim at gaining precise knowledge of the structure of macromolecules, which is essential to understand how they function. Experimental genomics and neuro-genomic activities will generate a plethora of new proteins and putative targets for treating diseases. In this context, structural biologists at the Human Technopole will seek to characterize the 3D structures of these targets to elucidate their functions and mode of action, as well as for drug discovery endeavors.
Center for Analysis, Decisions, and Society
A joint project with the Politecnico di Milano. It is envisioned to develop original research at the intersection of computer science, mathematics, statistics, artificial intelligence, and socioeconomic sciences. The aim is to analyse in an integrated fashion large-scale genomics data, personalised medicine and lifestyle data, and information generated by the healthcare system on treatment effectiveness and ultimately economics.